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CropLife: Novel Mode Of Action Spurs Committee To Create New FRAC Group For Fracture® Fungicide

Thursday March 24th, 2016

Via Croplife:

The Fungicide Resistance Action Committee (FRAC) has assigned Fracture® fungicide from FMC to a newly created FRAC Group. When FMC launched Fracture® fungicide in 2015, the broad spectrum, biological fungicide formulated with ProBLAD technology had such a unique mode of action that it could not be classified by current FRAC Group codes.

FRAC codes are created by the Fungicide Resistance Action Committee to group fungicide active ingredients by modes and sites of action to prolong the effectiveness of at-risk fungicides and to limit crop losses should resistance occur. The FRAC codes also help growers and PCAs identify which products to rotate to maintain effective disease control and minimize resistance development.

The Committee recently added the new FRAC Group M12 for Fracture® fungicide and its active ingredient, the lupine extract called BLAD. Like other M group classifications, Fracture® fungicide has “multi-site contact activity” and is considered a low risk for development of resistance, according to the FRAC publication.

Fracture® fungicide provides decisive, multi-site control in a way no other fungicide can claim. It works on contact by binding to the fungal cell and deforming the chitin, disrupting nutrient absorption and inhibiting fungal cell production. This action tears a hole in the cell wall and ultimately destroys the fungal cell. Within eight hours, the fungal cell is dead.

“The assigning of Fracture® fungicide to the new FRAC Group M12 demonstrates its value as a powerful resistance management tool. In the FRAC system, ‘M’ group fungicides are considered the best for fighting resistance due to the fact that they attack multiple sites within the fungus,” said David Davies, FMC Agricultural Solutions North America segment manager. “By offering an entirely new mode of action that complements synthetic fungicides, Fracture® fungicide expands growers’ options and will help extend the lifespan of other chemistries.”

Fracture® fungicide is labeled for the prevention and control of powdery mildew, botrytis, and brown rot blossom blight. It is a patented fungicide labeled for use in the U.S. on almonds, grapes, strawberries, and tomatoes. With a one-day pre-harvest interval and a four-hour re-entry interval, Fracture® fungicide can be applied up to five times per season, providing growers with a flexible management tool that offers quick, reliable disease control that meets or exceeds established standards.

Ecotoxicology studies conducted to meet regulatory requirements have shown Fracture® fungicide is nontoxic to adult bees, bee larvae, beneficial parasitic wasps and predatory mites. Fracture® fungicide should be used as part of a complete spray program for disease control and resistance management.

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